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Communication | Regular issue | Vol 24, No. 12, 1986, pp.3351-3358
Published online, 1st January, 1970
DOI: 10.3987/R-1986-12-3351
Demalonylcopiamycin, a New Antibiotic Produced by Streptomyces hygroscopicus var. crystallogenes, the Copiamycin Source

Toshio Fukai, Taro Nomura,* Jun Uno, and Tadashi Arai

*Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan


Demalonylcopiamycin (1) was isolated from the mycelial cake of Streptomyces hygroscopicus var. crystallogenes. The structure was determined by the identification of 1 with alkaline hydrolysis product of copiamycin (2). The new antibiotic (1) was found to be more active against Gram-positive bacteria than copiamycin (2), while slightly more active against fungi.