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Paper | Regular issue | Vol 24, No. 11, 1986, pp.3199-3201
Published online, 1st January, 1970
DOI: 10.3987/R-1986-11-3199
Synthesis of 4-Substituted 3-Pyridyl Ketones

Daniel L. Comins* and Eric D. Stroud

*Department of Chemistry abd Biochemistry, Utah State University, Logan, Utah 84332-0300, U.S.A.


In the presence of a catalytic amount of cuprous iodide, the addition of Grignard reagents to the 1-phenoxycarbonyl salts of 3-acylpyridines gives 3-acyl-4-alkyl-1-phenoxycarbonyl-1,4-dihydropyridines. The crude dihydropyridines were aromatized with hot sulfur to give 4-substituted 3-pyridyl ketones.