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Paper | Regular issue | Vol 24, No. 11, 1986, pp.3195-3198
Published online, 1st January, 1970
DOI: 10.3987/R-1986-11-3195
Synthesis of Substituted 4,5-Dihydro-4-oxo-2-[(2-trans-phenylcyclopropyl)amino]-3-furancarboxylic Acids and Ethyl Esters

Vassil St. Georgiev,* Robert A. Mack, and C. Richard Kinsolving

*Department of Organic Chemistry, Pharmaceutical Division, Pennwalt Corporation, Rochester, New York 14623, U.S.A.


The synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-2-[(2-trans-phenylcyclopropyl)amino]-3-furancarboxylic acids and their ethyl esters, is described. When tested in broth and agar dilution tests, some of the title compounds exerted in vitro antimicrobial activity against a number of gram-positive and gram-negative bacteria, as well as in vitro antifungal activity against dermatophyte and yeast fungi.