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Paper | Regular issue | Vol 24, No. 11, 1986, pp.3143-3148
Published online, 1st January, 1970
DOI: 10.3987/R-1986-11-3143
Pyrazolo[1’,5’:1,6]pyrimido[4,5-d]pyridazin-7(8H)-one: A New Heterocyclic Ring System from Isoxazolopyridazinones

Vittorio Dal Piaz,* Giovanna Ciciani, and Stefano Chimichi

*Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via Gino Capponi 9, I-50121 Firenze, Italy

Abstract

Treatment of isoxazalo[3,4-d]pyridazin-7(6H)-ones (1a-d) with hydrazine afforded the pyrazole derivatives (3a-d) which were converted in high yields into the new pyrazolo[1’,5’:1,6]pyrimido[4,5-d]pyridazin-7(8H)-ones (4a-d) by ring-closure with acetic anhydride.