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Communication | Regular issue | Vol 24, No. 11, 1986, pp.3047-3052
Published online, 1st January, 1970
DOI: 10.3987/R-1986-11-3047
Organogerminium Compounds: First General Methods for Synthesis of Bioactive Trithiagermatranes with Novel Functional Groups

Norihiro Kakimoto,* Katsuyuki Sato, Masanao Matsui, Toyozo Takada, and Mitsuo Akiba

*Asai Germanium Research Institute, 1-6-4, Izumihon-cho, Komae-shi Tokyo 201, Japan


The first general methods for the synthesis of 1-substituted trithiagermatranes (3) have been developed using the reaction of tris-(2-mercaptoethyl)amine with trimethoxygermyl compounds (5), sesquioxides (6) and sesquisulfides(7). These newly prepared compounds were found to have the capacity to relieve pain, thus indicating them to have strong inhibitory activity toward a decomposition enzyme for enkephalin which is an opioid peptide in a living body.