Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 24, No. 10, 1986, pp.2887-2900
Published online, 1st January, 1970
DOI: 10.3987/R-1986-10-2887
Synthesis and Phermacodynamic Investigation of New Isoguvacine Analogues with Benzoquinolizine Skeleton

Gábor Blaskó, Julianna Kardos, Eszter Baits-Gács, Miklós Simonyi, and Csaba Szántay*

*Central Research Institute for Chemistry, Hungarian Academy of Sciences, H-1025 Budapest, Pusztaszeri ut 59-67, P.O.Box 17, Hungary


Stereoisomer hydroxy-esters 15 -19 as well as isoguvacine analogue 20 with benzo[a]quinolizine skeleton have been prepared via regioselective Dieckmann condensation of diester 9 followed by subsequent reduction and E2-elimination. Compounds 16 and 20 have shown a considerable in vitro activity at the GABA/benzodiazepine receptor complex.