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Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Paper | Regular issue | Vol 24, No. 9, 1986, pp.2487-2491
Published online, 1st January, 1970■ Synthesis of a Cimetidine Analogue
Published online, 1st January, 1970
DOI: 10.3987/R-1986-09-2487
■ Synthesis of a Cimetidine Analogue
József Heiszman, Kálmán Harsányi, and László Töke*
*Department of Organic Chemical Technology, Technical University of Budapest, H-1521 Budapest, Gellért tér 4, Hungary
Abstract
2-Hydroxymethyl-4-methylimidazole(2a) and 2,5-bis(hydroxymethyl)-4-methylimidazole(3a) have been synthesized and characterized. No reaction on the hydroxymethyl moieties in position 2 of these compounds could be observed with cysteamine under usual reaction conditions. The hydroxymethyl group in position 5 of compound 3a does react with cysteamine to give an intermediate leading to 3b and to cimetidine analogue 3c.
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