Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 24, No. 9, 1986, pp.2487-2491
Published online, 1st January, 1970
DOI: 10.3987/R-1986-09-2487
Synthesis of a Cimetidine Analogue

József Heiszman, Kálmán Harsányi, and László Töke*

*Department of Organic Chemical Technology, Technical University of Budapest, H-1521 Budapest, Gellért tér 4, Hungary


2-Hydroxymethyl-4-methylimidazole(2a) and 2,5-bis(hydroxymethyl)-4-methylimidazole(3a) have been synthesized and characterized. No reaction on the hydroxymethyl moieties in position 2 of these compounds could be observed with cysteamine under usual reaction conditions. The hydroxymethyl group in position 5 of compound 3a does react with cysteamine to give an intermediate leading to 3b and to cimetidine analogue 3c.