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Communication | Regular issue | Vol 24, No. 8, 1986, pp.2141-2145
Published online, 1st January, 1970
DOI: 10.3987/R-1986-08-2141
Kazinol P, a Novel Isoprenylated Spiro-compound from Broussonetia kazinoki Sieb.

Susumu Kato, Yoshio Hano, Toshio Fukai, Yasumi Kosuge, and Taro Nomura*

*Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan


A novel isoprenylated spiro-compound named kazinol P (1) was isolated from a benzene extract of the root bark of Broussonetia kazinoki Sieb. (Japanese name “Himekozo”, Moraceae). The structure was shown to be 1 on the basis of spectral evidence. Kazinol P is regarded biogenetically as a variation of a flavan and/or a 1,3-diphenylpropane derivative, such as kazinol E (2) and kazinol C (6).