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Paper | Regular issue | Vol 24, No. 7, 1986, pp.1977-1985
Published online, 1st January, 1970
DOI: 10.3987/R-1986-07-1977
Synthesis of 2-Substituted-6,7-dihydro-4H-pyrimido[6,1-a]thieno[2,3-c]- and [3,2-c]pyridin-4-ones

Bansi Lal,* Lalitha Krishnan, and Noel J. de Sauza

*Department of Chemistry, Research Centre, Hoechst India Limited, Mulund, Bombay 400 080, India

Abstract

1-(2-(3-Thienyl)ethyl)barbituric acid (7a) and 1-(2-(2-thienyl)ethyl)barbituric acid (7b) were cyclized to novel 2-chloro-6,7-dihydro-4H-pyrimido[6,1-a]thieno[2,3-c]pyridin-4-one (8a) and 2-chloro-6,7-dihydro-4H-pyrimido[6,1-a]thieno[3,2-c]pyridin-4-one (8b), respectively. The chloro group in both 8a and 8b was displaced by different amines to give the corresponding amino compounds 9a and 9b.