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Paper | Regular issue | Vol 24, No. 7, 1986, pp.1955-1961
Published online, 1st January, 1970
DOI: 10.3987/R-1986-07-1955
Spectroscopic Analysis of Iodinated Molecular Complexes of N-Methylimidazole and Other Imidazole and Imidazoline Derivatives of Pharmacological Importabce

Anne-Catherine Jambut-Absil, Jacques Buxeraud, Chiristian Moesch, Jean-François Lagorce, and Claude Raby*

*Department de Chimie Therapeutique, UFR de Pharmacie, 2, rue du Docteur Marcland, 87025 Limoges Cedex, France

Abstract

Molecular interactions between iodine and heterocyclic molecules such as N-methylimidazole, methimazole, clotrimazole, levamisole and tetrahydrozoline were investigated by UV/Vis spectroscopy. Iodine was found to form charge transfer complexes with these molecules of 1:1 stoichiometry of the n-o type. The values of the formation constants Kc of these iodinated complexes indicated a strong donor-acceptor interaction. These compounds can therefore be expected to have an action on thyroid metabolism.