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Paper | Regular issue | Vol 24, No. 7, 1986, pp.1931-1941
Published online, 1st January, 1970
DOI: 10.3987/R-1986-07-1931
Synthesis of 5-Oxo-5H-[1]benzopyrano[4,3-b]pyridine Derivatives

Kiyoshi Ukawa, Toshihiro Ishiguro,* Yoshikazu Wada, and Akira Nohara

*Central Research Division, Takeda Chemical Industries, Ltd., 17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan

Abstract

5-Oxo-5H-[1]benzopyrano[4,3-b]pyridine-3-carboxamides (2) were synthesized by the reaction of 4-oxo-4H-1-benzopyran-3-carbonitriles (1) with malonamide in the presence of sodium methoxide. Compounds (2) were also converted into carboxylic acids and tetrazole derivatives. The structures of 2 and their derivatives were confirmed by IR and NMR spectra and by X-ray crystallographic analysis.