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Report | Regular issue | Vol 24, No. 6, 1986, pp.1585-1588
Published online, 1st January, 1970
DOI: 10.3987/R-1986-06-1585
A Convenient Synthesis of 5-(4-Pyridinyl)-2(1H)-pyridones

Woei-Ping Fang, Puh Shieh, and Min-Jen Shiao*

*Institutue of Chemistry, Academia Sinica, 128, Yan-Chiu-Yuan Road, Sec II, Nankang, Taipei,11529, Taiwan, R.O.C.


A convenient synthesis of 3,4-bipyridine derivatives is reported. The addition of lithium salt derived from 2-alkoxy-5 bromopyridines 3a and 3b to N-ethoxycarbonylpyridinium chloride 4a gave the corresponding unstable 1,4-dihydropyridines which were readily oxidized by air to the 3,4’-bipyridines 6a and 6b. Compounds 6a and 6b can he converted into 5-(4-pyridinyl)-2(1H)-pyridones by hydrogenolysis and by alkylation in basic conditions.