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Report | Regular issue | Vol 24, No. 5, 1986, pp.1287-1289
Published online, 1st January, 1970
DOI: 10.3987/R-1986-05-1287
Synthesis of (2S,5S)-2,5-Bis(phenylmethyl)piperazine by the Reduction with Sodium Borohydride Using Titanium Tetrachloride

Kenso Soai,* Hiroshi Hayashi, and Hitoshi Hasegawa

*Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka 1-3, Shinjuku-ku, Tokyo 162-8601, Japan


Optically active piperazine 1 is synthesized in relatively high yield by the reduction of cyclo-L-Phe-L-Phe with sodium borohydride-titanium tetrachloride.