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Communication | Regular issue | Vol 24, No. 5, 1986, pp.1197-1201
Published online, 1st January, 1970
DOI: 10.3987/R-1986-05-1197
Asimicin, a New Cytotoxic and Pesticidal Acetogenin from the Pawpaw, Asimina triloba (Annonaceae)

J. Kent Rupprecht, Ching-jer Chang, John M. Cassady, Jerry L. McLaughlin,* Kenneth L. Mikolkajczak, and David Weisleder

*Department of Medicinal Chemistry and Molecular Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, 1333 Robert E. Heine Pharmacy Building, West Lafayette IN 47907, U.S.A.


Asimicin, a new trihydroxy-bistetrahydrofuran fatty acid γ-lactone has been isolated, using brine shrimp lethality for activity-directed fractionation, from extracts of the bark and the seeds of the pawpaw tree, Asimina triloba Dunal. (Annonaceae). This compound is extremely cytotoxic and shows promising pesticidal activities.