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Communication | Regular issue | Vol 24, No. 4, 1986, pp.885-888
Published online, 1st January, 1970
DOI: 10.3987/R-1986-04-0885
The Preparation of Aza-β-lactam, 1,3,4-Thiadiazine, β-Lactam, and 1,3,4-Thiadiazepine Derivatives by the Reaction of Thiosemicarbazidines with α- and β-Haloacyl Halides

Tadashi Okawara, Rie Kato, Tetsuo Yamasaki, Naohiko Yasuda, and Mitsuru Furukawa*

*Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan


The reaction of thiosemicarbazide (I) with α- and β-haloacyl halides provided aza-β-lactam (III), 1,3,4-thiadiazine (V) , β-lactam (X) , and 1,3,4-thiadiazepine (XI and XII) derivatives under two phase conditions.