Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Report | Regular issue | Vol 24, No. 2, 1986, pp.345-347
Published online, 1st January, 1970
DOI: 10.3987/R-1986-02-0345
Racemic and Chiral Syntheses of the Alangium Alkaloid Alancine

Tozo Fujii,* Masashi Ohba, Asako Yonezawa, Jun Sakaguchi, Sunil K. Chattopadhyay, David J. Slatkin, Paul L. Schiff, Jr., and Anli B. Ray

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan

Abstract

(±)-Alancine [(±)-I] has been synthesized in good yield from the tricyclic amino acid (±)-V by catalytic hydrogenolysis. Treatment of (±)-I with aqueous HCl gave the hydrochloride salt (±)-I·HCl. A parallel synthesis starting with (-)-V produced (-) -alancine [(-)-I] as well as its hydrochloride (-) -I·HCl in good yields. The synthetic (-)-I·HCl was found to be identical with a sample isolated from Alangium lamarckii Thw.