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Paper | Regular issue | Vol 24, No. 1, 1986, pp.143-154
Published online, 1st January, 1970
DOI: 10.3987/R-1986-01-0143
Polycyclic N-Hetero Compounds. XXI. Synthesis of Novel Ring System, 4H-Imidazo[1’,2’:1,6]pyrimido[5,4-d][1]benzazepine as B-Homo-6,11,13,15-tetraazastereoidal Analogue

Takashi Hirota,* Masami Fukukoto, Kenji Sasaki, Tetsuo Namba, and Shohei Hayakawa

*Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan

Abstract

A synthesis of 4H-imidazo[1’,2’:1,6]pyrimido[5,4-d][1]benzazepine (XIIIa) having a novel ring system is described. Methyl anthranilate (IVa) was converted to 4-(2-hydroxyethylamino)-6,7-dihydro-5H-primido[5,4-d][1]benzazepine (XIa) in several steps and XIa was cyclized to XIIIa. A synthesis of 8-chloro derivative of XIIIa is also described.