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Paper | Regular issue | Vol 24, No. 1, 1986, pp.87-91
Published online, 1st January, 1970
DOI: 10.3987/R-1986-01-0087
On the Reactiond of 2-Chloronicotinic Acid with 2-Aminobenzothiazole

Javier Garin, Enrique Meléndez, Francisco L. Merchan,* and Tomás Tejero

*Department of Chemistry, University of Zaragoza, 50009-Zaragoza, Spain

Abstract

The results of the reaction of 2-chloronicotinic acid with a series of 2-aminobenzothiazoles are reported. Under reflux of xylene the major product is the corresponding N-(2-benzothiazolyl)-1,2-dihydro-2-oxonicotinamide. Its structure is confirmed by an alternative synthesis and a possible explanation for its formation is provided. The results of the reaction of 2-aminobenzothiazole with 2-chloronicotinoyl chloride and methyl 2-chloronicotinate are also summarized.