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Communication | Regular issue | Vol 23, No. 11, 1985, pp.2803-2806
Published online, 1st January, 1970
DOI: 10.3987/R-1985-11-2803
One Pot Synthesis of Quinazoline Derivatives by Use of Palladium Catalyzed Carbonylation

Miwako Mori, Hiromi Kobayashi, Masaya Kimura, and Yoshio Ban*

*Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

One pot synthesis of quinazoline derivatives from a mixture of o-iodoaniline 1a and five membered lactams or N-acyl-o-iodoaniline derivatives, 1b and 1c, and primary amines was effected through the palladium-catalyzed insertion of carbon monoxide.