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Report | Regular issue | Vol 23, No. 10, 1985, pp.2577-2581
Published online, 1st January, 1970
DOI: 10.3987/R-1985-10-2577
■ N-Dideuterobutyryldeacetylcolchicine: Probes to Study Colchicine Binding Sites on Tubulin Protein

Maria A. Iorio, Antonio Doldo, Arnold Brossi,* and Colin F. Chignell

*Section of Medical Chemistry, Section of Medical Chemistry, National Institute of Health, Bethesda, MD 20982, U.S.A.

Abstract

N-Acryloyl- and N-crotonyldeacetylcolchicine prepared from deacetylcolchiceine by conventional methods showed good binding to tubulin protein in vitro. N-Dideuterobutyryldeacetylcolchicine, prepared from deacetylcolchicine with dideuterobutyryl chloride behaved similarly, suggesting that tritiated analogs of N-propionyl- and N-butyryldeacetylcolchicine should be useful probes to study the colchicine binding site on tubulin protein.