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Report | Regular issue | Vol 23, No. 9, 1985, pp.2367-2369
Published online, 1st January, 1970
DOI: 10.3987/R-1985-09-2367
New Method and Reagents in Organic Synthesis. 53. Lithium Trimethylsilyldiazomethane: a New Synthon for the Preparation of 2-Amino-1,3,4-thiadiazoles from Isothiocyanates

Toyohiko Aoyama,* Mototsugu Kabeya, Atsuko Fukushima, and Takayuki Shioiri

*Faculty of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan


Lithium trimethylsilyldiazomethane reacts smoothly with isothiocyanates in diethyl ether to give 2-amino-1,3,4-thiadiazoles in good yields.