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Report | Regular issue | Vol 23, No. 9, 1985, pp.2339-2345
Published online, 1st January, 1970
DOI: 10.3987/R-1985-09-2339
Pyrolytic Products of N-Alkyl-N‘-(4-methyl-2-thiazolyl)-S-methylisothioureas

Reiko Yoda,* Yuichi Yamamoto, Tomoko Okada, and Yoshikazu Matsushima

*Faculty of Pharmaceutical Sciences, Kyoritsu College of Pharmacy, 1-5-30, Shiba-koen, Minato-ku, Tokyo 105-8512, Japan


N-Methyl-N’-(4-methyl-2-thiazolyl)-S-methylisothiourea (1a) was pyrolyzed at 155°C, for 14 h. N-Methyl-N’,N”-bis(4-methyl-2-thiazolyl)guanidine (2a) was identified as the product. 3-Methyl-thiazolyl compounds such as N-methyl-N’-(3,4-dimethyl-2(3H)thiazolylidene)thiourea (3a) and N-methyl-N’-(3,4-dimethyl-2-thiazolyl)-N”-(4-methyl-2-thiazolyl)guanidine (6a) were not obtained in the pyrolysis, in contrast to the previous finding that a main pyrolytic product of N,N-dimethyl-N’-(4-methyl-2-thiazolyl)-S-methylisothiourea was N,N-dimethyl-N’-(3,4-dimethyl-2(3H)thiazolylidene)thiourea.