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Report | Regular issue | Vol 23, No. 9, 1985, pp.2327-2333
Published online, 1st January, 1970
DOI: 10.3987/R-1985-09-2327
Palladium-catalyzed Coupling Reaction of Chloropyrazines with Indole

Yasuo Akita, Akira Inoue, Keiko Yamamoto, Akihiro Ohta,* Teruo Kurihara, and Mitsuru Shimizu

*Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

The palladium-catalyzed cross-coupling reaction of 2-chloropyrazines with indole was shown to proceed in moderate to good yields, giving 2-(pyrazin-2-yl)indoles. The structure determination of the products was made on the basis of the X-Ray diffraction and 13C-NMR spectroscopic analyses.