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Report | Regular issue | Vol 23, No. 9, 1985, pp.2255-2270
Published online, 1st January, 1970
DOI: 10.3987/R-1985-09-2255
2-(Heteroatom-substituted)methyl Penems. I. Sulphur Derivatives

Marco Alpegiani, Angelo Bedeschi, Ettore Perrone,* Franco Zarini, and Giovanni Franceschi

*Ricerca&Sviluppo Chimico, Farmitalia Carlo Erba SpA, Via dei Gracchi 35, 20146 Milano, Italy

Abstract

Chemical strategies for the synthesis of “2-CH2X” penems wherein X is a (substituted) alkylthio or heterocyclylthio radical are reviewed. The rationale at the basis of the programme is checked against the obtained microbiological data.