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Communication | Regular issue | Vol 23, No. 9, 1985, pp.2213-2215
Published online, 1st January, 1970
DOI: 10.3987/R-1985-09-2213
Chemistry of Metallo-ketene-S,N-acetals. New Synthesis of Azacycloalka[2,3-d]pyrimidines

Hiroki Takahata, Toshiaki Suzuki, and Takao Yamazaki*

*Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Toyama 930-0194, Japan


Bis-lithio-ketene-S,N-acetals, generated from thiolactams by treatment with n-BuLi, react with aryl isothiocyanates to give dithioamides. Bismethylation of the dithioamides followed by condensation with benzamidine affords the azacycloalka[2,3-d]pyrimidines.