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Communication | Regular issue | Vol 23, No. 9, 1985, pp.2197-2200
Published online, 1st January, 1970
DOI: 10.3987/R-1985-09-2197
Synthesis of 5-[1-(3-Methoxycarbonyl)-O-methylpseudoureido]uracil: A Novel Method for the Conversion of an N,N‘-Disubstituted Thiourea into an O-Methyl-N,N‘-disubstituted Pseudourea

Ji-Wang Chern, Dean Sylvester Wise, Jr., and Leroy B. Townsend*

*Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, 308 Harvard St., S. E., Minneapolis, Minnesota 55455, U.S.A.


Treatment of 5-[1-(3-methoxycarbonyl)thioureido]uracil with dicyclohexylcarbodiimide in methanol has resulted in the formation of 5-[1-(3-methoxycarbonyl)-O-methylpseudoureido]uracil.