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Communication | Regular issue | Vol 23, No. 8, 1985, pp.1947-1950
Published online, 1st January, 1970
DOI: 10.3987/R-1985-08-1947
Cyclization of Dinitriles by Hydrogen Halides. 1. Hydrogen Bromide. The Temperatures as a Novel Determining Factor of the Direction of Cyclization

Pedro Victory* and Miquel Garriga

*Departmento de Química Orgánicam Instituto Químico de Sarriá, Universitat de Barcelona, 08028 Barcelona, Spain


A selective synthesis of the 2-amino-4-bromo- and 4-amino-2-bromo-5,6-dihydro-5-methylpyrido[2,3-d]pyrimidin-7(8H)-ones (2 and 3) by temperature control in the cyclization reaction of the 6-cyanamino-5-cyano-3,4-dihydro-4-methyl-2-pyridone (1) with hydrogen bromide is described. The structure of the isomer obtained in each case is assigned unequivocally.