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■ On the Catalytic Reduction of Some 12-Spiro-derivatives of 8-Aza-11-oxasteroids

Cosimo Altomare, Francesco Campabna, Angelo Carotti,* and Wayne E. Steinmetz

*Dipartimento Farmaco-Chimico, Università di Bari, Via Amendola 173, 70126 Bari, Italy

Abstract

The catalytic reduction over Pd on carbon of some 8-aza-11-oxo-gona- and D-homo-gona-1,3,5(10),6,13-pentaene derivatives 1, carrying either a barbituric or a 1,3-indandione moiety as the spira-substituent at C-12, is reported. Different spectral means, including proton-proton nuclear Overhauser effect (nOe) measurements, have been used to get structure elucidation. A detailed analysis of the ¹H-NMR spectra at 400 MHz of some reduction products is also reported.