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Communication | Regular issue | Vol 23, No. 8, 1985, pp.1881-1884
Published online, 1st January, 1970
DOI: 10.3987/R-1985-08-1881
A Versatile One-pot Synthesis of Symmetrical N-Tosylazamacrocycles

Sebastiano Pappalardo,* Francesco Bottino, Michele Di Grazia, Paolo Finocchiaro, and Antonino Mamo

*Dipartimento di Scienze Farmaceutiche , Università di Catania, Viale A. Doria 6, 95125 Catania, Italy

Abstract

A variety of title compounds (azacrown ethers, pyridino-azacrown analogues and azacyclophanes) have been synthesized in moderate to good yield by coupling appropriate bis(halomethyl) or bis(tosylate ester) precursors with tosylamide monosodium salt. A revised mechanism is proposed.