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Review | Regular issue | Vol 23, No. 7, 1985, pp.1765-1813
Published online, 1st January, 1970
DOI: 10.3987/R-1985-07-1765
Kinetics and Mechanisms of Nucleophilic Displacements at sp3 Hybridized Carbon Atoms with Heterocyclic Leaving Groups

Alan R. Katritzky,* Kumars Sakizadeh, and Giuseppe Musumarra

*Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, Florida 32611-7200, U.S.A.


Following a description of experimental methods, kinetic results are summarized, dealing successively with 2nd order and 1st order rates. In each of these sections, studies of product formation are described, followed by the effects of leaving group (steric and electronic), alkyl group structure, solvent, nucleophile and temperature. Finally, overall conclusions are presented together with the outlook for further work.