Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Report | Regular issue | Vol 23, No. 7, 1985, pp.1685-1689
Published online, 1st January, 1970
DOI: 10.3987/R-1985-07-1685
Regioselective Synthesis of N-1 and N-2 Substituted Pyrimidinones Employing a Novel 1,3-Oxazine Preparation

Harvey I. Skulnick and Wendell Wierenga*

*CNS Research, The Upjohn Company, Kalamazoo, MI 49001, U.S.A.

Abstract

Reaction of ethyl benzoylacetate with methylthiopseudourea resulted in expulsion of methylmercaptan to afford 2-amino-6-phenyl-4H-1,3-oxarin-4-one in good yield. This novel oxazine synthesis was exploited to secure N-1 and N-2 substituted pyrimidinones regiospecifically.