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Report | Regular issue | Vol 23, No. 7, 1985, pp.1651-1657
Published online, 1st January, 1970
DOI: 10.3987/R-1985-07-1651
Synthesis of Some Isomeric 4H,10H[1]benzoxepino[4,3-d]isoxazol-4-ones and 4H,10H[1]benzoxepino[3,4-c]isoxazol-4-ones and Benzothiepino Analogs

Christian Deshayes, Michel Chabannet, Boubker Najib, and Suzanne Gelin*

*Département de Biochimie, Laboratoire de Chimie Organique, Institut National des Sciences Appliquées, 20 Avenue Albert Einstein 69621 Villeurbanne Cedex, France


The regiospecific formation of 5- or 3-(phenoxymethyl) or 5- or 3-(phenylthiomethyl)isoxazole-4-carboxylic acids is described. These isoxazoles are utilized as the starting material for the synthesis of isomeric 4H,10H[1]benzoxepino[4,3-d] or [3,4-c]isoxazol-4-one derivatives and benzothiepino analogs.