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Report | Regular issue | Vol 23, No. 7, 1985, pp.1645-1649
Published online, 1st January, 1970
DOI: 10.3987/R-1985-07-1645
The Sequential Lithiation of 1-Phenyl-1,2,4-triazoles

Ronald G. Micetich,* Paul Spevak, Tse W. Hall, and Baljit K. Bains

*Faculty of Pharmacy , University of Alberta, Edmonton, Alberta T6G, 2N8, Canada


1-Phenyl-1,2,4-triazole is lithiated exclusively at the C-5 position. 5-Methyl-1-phenyl-1,2,4-triazole produces the 5-lithiomethyl derivative; while the 5-ethyl, 5-methoxymethyl, and 5-acetic acid derivatives af 1-phenyl-1,2,4-triazole undergo exclusive lithiation of the C-5-methylene group. 5-Thiomethyl-1-phenyl-1,2,4-triazole is lithiated on the C-5 thiomethyl group.