Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 23, No. 7, 1985, pp.1603-1606
Published online, 1st January, 1970
DOI: 10.3987/R-1985-07-1603
A Photochemical Route to Pyrrolo[1,4]benzodiazepine Antitumor Antibiotics

Paul H. Mazzocchi* and Ann DeCamp Schuda

*Department of Chemistry, University of Maryland, College Park, Marykland 20742, U.S.A.


The parent pyrrolo[1,4]benzodiazepine ring system was synthesized. The key step was the photostimulated ring expansion reaction of N-pentenylphthalimide to give a pyrrolobenzazepinedione photoproduct. Conversion of the pyrrolobenzazepinedione ring system to the pyrrolo[1,4]benzodiazepine ring system was accomplished in several steps with the key step a Curtius rearrangement.