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Report | Regular issue | Vol 23, No. 6, 1985, pp.1479-1482
Published online, 1st January, 1970
DOI: 10.3987/R-1985-06-1479
A Novel Synthesis of 1,6-Dihydro-2-methyl-6-oxo[3,4’-bipyridine]-5-carbonitrile (Milrinone)

Baldev Singh*

*Sterling Research Group, Rensselaer, New York 12144, U.S.A.


Milrinone (3) was prepared either by reacting ethoxymethylenemalononitrile with 1-(4-pyridinyl)-2-propanone or malononitrile with 4-ethoxy-3-(4-pyridinyl)-3-buten-2-one.