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Communication | Regular issue | Vol 23, No. 6, 1985, pp.1385-1390
Published online, 1st January, 1970
DOI: 10.3987/R-1985-06-1385
A Short Synthesis of Rutecarpine and/or Vasicolinone from 2-Chloro-3-(indol-3-yl)ethylquinazolin-4(3H)-one: Evidence for the Participation of the Spiro Intermediate

Chikara Kaneko,* Takuo Chiba, Kouichi Kasai, and Chiemi Miwa

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

A new route to rutecarpine and/or vasicolinone from 2-chloro-4-quinazolone through an acid catalyzed cyclization of 2-chloro-3-indolylethylquinazolin-4-one has been developed and the mechanism of the cyclization reaction clarified.