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Communication | Regular issue | Vol 23, No. 6, 1985, pp.1353-1356
Published online, 1st January, 1970
DOI: 10.3987/R-1985-06-1353
Amidoalkylation of Aromatic Compounds with Methylglyoxal-bismethylcarbamate. A New Synthesis of 1-Amino-1-phenyl-2-propanone Derivatives and Substituted Benzofurans

Dov Ben-Ishai* and Daniella Denenmark

*Department of Chemistry, Israel Institute of Technology, Haifa 32000, Israel


The synthesis of 1-methoxycarbonylamino-1-aryl-2-propanones 4 and 3-methoxy carbonylamino-3-methylbenzofurans 7 by the direct amidoalkylation of aromatic compounds with methylglyoxal-bismethylcarbamate (3) is described. The amidopropanones (4) were further converted to the corresponding amidopropanols (5) and 2-oxazolidinones (6).