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Communication | Regular issue | Vol 23, No. 4, 1985, pp.839-842
Published online, 1st January, 1970
DOI: 10.3987/R-1985-04-0839
Total Synthesis of (-)-Antirhine

Toshio Suzuki,* Etsuko Sato, Katsuo Unno, and Tetsuji Kametani

*Department of Pharmaceutical Sciences, Akita University Hospital, Hondo, Akita 010, Japan

Abstract

Total synthesis of (-)-antirhine (6) has been achieved from a potentially useful chiral synthon, (3S)-[3-hydroxy-(E)-prop-1-enyl]cyclopentanone (1), via β,γ-unsaturated aldehyde (5), which was obtained by mild hydrolysis of α-cyano-N,N-dimethylaminocyclopentanone (7).