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Report | Regular issue | Vol 23, No. 2, 1985, pp.387-390
Published online, 1st January, 1970
DOI: 10.3987/R-1985-02-0387
Synthesis of Novel Quinoline Quinols and Isoquinoline Quinols from Quinones

Akinori Kubo,* Yoshiyasu Kitahara, Katsutoshi Inaba, Shin-ishiro Sakai, and Keiichi Yamaguchi

*Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan


Quinoline quinols and Isoquinoline quinols were synthesized from the corresponding quinoline quinones and isoquinoline quinones, respectively, by the series of reactions, protection of one carbonyl with trimethylsilyl cyanide, reaction with methyl lithium or the enolate of methyl acetate, and hydrolytic deprotection with aqueous silver fluoride.