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Communication | Regular issue | Vol 23, No. 2, 1985, pp.277-280
Published online, 1st January, 1970
DOI: 10.3987/R-1985-02-0277
Total Synthesis of Kukoamine A Using 2-Methyl-5,6-dihydro-4H-1,3-oxazine as a Carboxamide Building Block

Toshio Moriwake,* Seiki Saito, Hideaki Tamai, Hitoshi Mitsuda, and Masami Inaba

*Faculty of Engineering, Okayama University, 3-1-1 Tsushima-naka, Okayama 700-8530, Japan

Abstract

Kukoamine A, the active constituent of Oriental medicine “Jikoppi” for hypertension, has been synthesized employing a new methodology for non-spermine-based polyamine construction.