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Communication | Regular issue | Vol 23, No. 2, 1985, pp.265-272
Published online, 1st January, 1970
DOI: 10.3987/R-1985-02-0265
A Novel Preparation of 4-Unsubstituted β-Lactams

Hans Rudolf Pfaendler* and Heike Hoppe

*Institut für Organische Chemie, Universität München, Karlstrasse 23, D-80333 München, Germany

Abstract

The key intermediate (1) for monobactam synthesis has been prepared from 6-aminopenicillanic acid (6-APA) without using Raney nickel. Desulfurisation was accomplished by a two step process, involving a novel reduction reaction.