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Communication | Regular issue | Vol 23, No. 2, 1985, pp.247-250
Published online, 1st January, 1970
DOI: 10.3987/R-1985-02-0247
Anodic Oxidation of N-Alkyl-β-lactams

Makoto Okita, Miwako Mori, Takeshi Wakamatsu, and Yoshio Ban*

*Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan


β-Lactams were electrolyzed in an undivided cell with platinum plate as anode in methanol under constant current. The oxidation of β-lactams 5 and α-methylene-β-lactams 10 proceeded both at the exo- and endo-cyclic carbons α to nitrogen, though five, six and seven membered lactams were regioselectively electrolyzed under the same conditions.