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Communication | Regular issue | Vol 23, No. 1, 1985, pp.45-49
Published online, 1st January, 1970
DOI: 10.3987/R-1985-01-0045
Fluorine-containing Amino Acids and Their Derivatives. 5. Synthesis of Novel Fluorinated Analogues of the Antitumor Agent, Methotrexate

Tadahiko Tsushima,* Kenji Kawada, Osamu Shiratori, and Naomi Uchida

*Shionogi Research Laboratories, Shionogi & Co. Ltd., Fukushima-ku, Osaka 553-0002, Japan

Abstract

Novel methotrexate analogues with γ-fluoro- or α-difluoromethyl-substitued-glutamic acid were synthesized for antitumor screening.