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Communication | Regular issue | Vol 23, No. 1, 1985, pp.25-27
Published online, 1st January, 1970
DOI: 10.3987/R-1985-01-0025
The Side-chain Acylamination of Alicyclic Nitrones. A New Synthsis of an α-Amino Acid

Dorota A. Abramovitch, Rudolph A. Abramovitch,* and Herman Benecke

*Department of Chemistry, Clemson University, Clemson, SC 29631, U.S.A.


2,4,4-Trimethyl-δ1-pyrroline-1- (4) and 2-n-butyl-4,4-dimethyloxazoline-3-oxide (6) are acylaminated in the presence of base at the α-position of the side-chain at C-2 to give 5 and 10, respectively. Ethanolysis of 10 gives the corresponding α-amino ester (11) in good yield.