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Communication | Regular issue | Vol 22, No. 10, 1984, pp.2263-2264
Published online, 1st January, 1970
DOI: 10.3987/R-1984-10-2263
A Total Synthesis of (±)-Corydaine from Coptisine

Miyoji Hanaoka,* Atsuyuki Ashimori, and Shingo Yasuda

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


Regioselective protection of C8-hydroxy of the spiro-diol (6b) derived from coptisine (1b), followed by oxidation of C13-hydroxy afforded the keto-oxazolidine (8b) which was treated with sodium cyanoborohydride to provide (±)-corydaine (5b) in an excellent yield.