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Communication | Regular issue | Vol 22, No. 10, 1984, pp.2259-2262
Published online, 1st January, 1970
DOI: 10.3987/R-1984-10-2259
Novel Synthesis of 2-Thiocytosine Derivatives via Pyrimidine-to-pyrimidine Ring Transformation

Kosaku Hirota,* Yukio Kitada, Hironao Sajiki, and Yoshifumi Maki

*Labolatory of Medicinal Chemistry, Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan


The reaction of 1,3-disubstituted 5-cyanouracils (1) with thioureas (2) and sodium hydroxide causes novel pyrimidine-to-pyrimidine ring transformation to give 2-thiocytosines (3) and 6-amino-5-formyluracils (4), respectively.