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Communication | Regular issue | Vol 22, No. 10, 1984, pp.2207-2211
Published online, 1st January, 1970
DOI: 10.3987/R-1984-10-2207
Contraction of the Tropolonic Ring of Colchicine by Hydrogen Peroxide Oxidation

Maria A. Iorio*

*Laboratorio di Chimica del Farmaco, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Roma, Italy

Abstract

By hydrogen peroxide oxidation of colchicine the tropolonic ring underwent contraction to a benzene ring. Two compounds were obtained and identified (EIMS, 1H NMR) as N-acetylcolchinol methyl ether and 10-carbomethoxy-N-acetylcolchinol. Antimitotic activity is also reported.