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Report | Regular issue | Vol 22, No. 9, 1984, pp.2071-2077
Published online, 1st January, 1970
DOI: 10.3987/R-1984-09-2071
Isolation of (—)-Stepholidine, an Alkaloid of Antiserotonergic-like Activity from Sinomenium acutum

Kazuo Ichikawa, Takeshi Kinoshita, Akiko Itai, Yoichi Iitaka, and Ushio Sankawa*

*Faculty of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan


A tetrahydroprotoberberine alkaloid, (-)-stepholidine (5), was isolated as an active principle showing antiserotonergic-like activity from Sinomenium acutum Rehder et Wilson (Menispermaceae) which has been used as an oriental medicinal drug (Japanese name, Bohi; Chinese name, Fang-Ji) in Japan. An aporphine type alkaloid, liriodenine (4), was isolated first time from this plant along with known alkaloids hitherto obtained from this plant.