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Communication | Regular issue | Vol 22, No. 9, 1984, pp.1975-1977
Published online, 1st January, 1970
DOI: 10.3987/R-1984-09-1975
The Synthesis of C-13 Labeled Vitamin E, [2a-13C]all-rac-α-Tocopherol

Shiro Urano* and Mitsuyoshi Matsuo

*Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-, Japan

Abstract

Vitamin E with a 13C-labeled isoprenoid side chain, [2a-13C]all-rac-α-tocopherol (1), was synthesized by condensation of trimethylhydroquinone with a mixture of [3a-13C]phytol (9a) and its geometrical isomer (9b). The 13C-labeled phytol was prepared using 5,9,13-trimethyltetradecan-1-al (6) as an intermediate and [13C]methyl iodide as a 13C source. The total yield of the labeled α-tocopherol was 65.4% on the basis of [13C]methyl iodide.