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Communication | Regular issue | Vol 22, No. 9, 1984, pp.1947-1949
Published online, 1st January, 1970
DOI: 10.3987/R-1984-09-1947
A New Vapor-phase Synthesis of Thiazoles

Joseph S. Amato,* Sandor Karady, Brian T. Phillips, and Leonard M. Weinstock

*Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065, U.S.A.


The vapor-phase reaction of imines with sulfur dioxide to produce thiazoles has been studied at 450-500°C. Of the imines investigated acetone methyl imine was the most studied which produced 4-methylthiazole in 70% yield.